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tumors that did develop appeared later and were smaller in size, and the total multiplicity of tumors per mouse was significantly reduced [62]

The raw datasets used and analyzed during the current study are available from the corresponding author upon request

There is no precise data available regarding the daily Phe tolerance in patients with BH 4 D and no precise data on the number of patients who, after being originally treated solely with a Phe-reduced diet, later switched to sapropterin dihydrochloride supplementation or a combined Phe-reduced diet plus sapropterin dihydrochloride treatment

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Animal Model:NMRI-Hannover (male, 30 g, deep partial skin thickness burns induced by 5 s direct flame exposure covering 20% total body area) [2] Dosage:i.p.: 10 ng/kg, 10 g/kg